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Leake County is served by three (3) major Mississippi
Highways.
Mississippi 35 is a major truck route connecting I-20 and I-55 which allows freight lines to avoid the Metro-Jackson area traffic. Highway 35 also connects Leake County southward to MS 49 and the Mississippi Gulf Coast and New Orleans.
Four-lane Mississippi 25 bisects Leake County connecting Leake County to Jackson, Starkville-Columbus, and North East Mississippi.
Mississippi 16 is the major east-west corridor through Leake County Connecting Leake County with Canton and I-55 and Philadelphia-Choctaw, Mississippi.
Leake County has easy access to Interstate-55 both at Canton and Vaiden. I-55 connects Leake County with Memphis, Tennessee; Saint Louis, Missouri; and Chicago to the north and to Baton Rouge, La. to the South where it connects with Interstate 65 and Interstate 10 to New Orleans.
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